N Radical Surgery (n) 40 8 110 4 2 (n) 128 65 Non Radical Surgery (n) 4 2 20 2 1 Total 44 10 130 6GEP > 자유게시판

프로젝트 :

업체명 : VE

담당자명 : Emmett Flood

연락처 : LA

이메일 : emmettflood@alice.it

N Radical Surgery (n) 40 8 110 4 2 (n) 128 65 Non Radical Surgery (n) 4 2 20 2 1 Total 44 10 130 6GEP gastroenteropancreatic, n number of patientsNikou et al. BMC Endocrine Disorders (2016) 16:Page 6 ofTable 6 Surgery and debulking procedures performed in NEN patients (n) with liver and lung metastasesNumber of patients Patients with Liver Metastases Liver Metastasectomy Chemoembolization Radiofrequency Ablation Other Patients with Lung Metastases Surgical Excision Total number: 49 6 3 4 2 Total number: 6 1 Primary Site (all Ki-67 Staurosporine 11 UP, 3 lung, 1 pheochromocyroma 4 GEP, 1 Lung, 1 unknown primary GEP GEP GEP 4 GEP, 1 lung, 1 unknown primary GEPGEP gastroenteropancreatic, UP unknown primaryDeaths observedDuring the follow-up period of the registry and at the time of the analyses 10 deaths were documented, corresponding to 4.1 of the registry population. The primary sites of origin of these patients were 6 gastroenteric, 2 pancreatic and 2 pheochromocytomas.Discussion This study presents for the first time the data of the NET registry in Greece focusing on the epidemiologic and clinico-pathologic characteristics as well as the therapeutic modalities applied in patients with all type of NENs except small and large cell lung cancer. Greece is a European country with a reported population of 11 million in 2012 (http://countryeconomy.com/ demography/population/greece). This partly explains the small number of recorded patients (246) presented in the participating centers during the first two years of this observational study. Taken into consideration that the eight centers participating in the study do not cover for the entire population definitive conclusions on the incidence of NEN tumors cannot be made. Only few cancer NEN registries exist in the USA and Europe, mostly national. According to the SEER database (seer.cancer.gov website), that includes information on 7,262,696 cancer patients, covering for 28 of the USA population the incidence of NENs in 2004 is 5.25/ 100.000 inhabitants [15]. On the other hand, data on the incidence of NENs in Europe, is limited and is usually reported by anatomic location, most commonly GEP NENs [8, 16]. Specifically, in one study including NENs of all sites, except lung, conducted by the RareCare Working Group, the overall incidence rate was 25/1,000,000 in total but it was highest when patients older than 65 years of age were considered (40 per 1,000,000) [17]. In our registry, the median age at diagnosis and the gender's ratio were in accordance to those reported in other published registries [4, 10, 12]. We found thegastroenteropancreatic tract being the most common followed by the head and neck and UP. This is slightly different from that reported in one study from the Mediterranean area with pancreas and lung being the commonest primaries, where it was found that 63 were GEP-NENs, 33 thoracic-NENs including thymic, 4 UP-NEN [10]. This difference is probably due to the fact that there was no center for lung NENs participating in our registry. With respect to the GI tract we found that gastric (35 ), pancreatic (23 ) and rectal NENs (12 ) were the commonest primary sites. An inverse frequency was PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/17139194 found in the Italian study as the pancreatic primary (31 ) was commonest compared to gastric (10 ) [10]. The presenting symptoms of our patients were related to endocrine syndrome in 24 , and to mass effect in 61 , most commonly dyspepsia, similarly to our previous retrospectiv.